The second is better. Both "and" and "however" are conjunctions. You can only use one at a time.
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vsureshPlease tell me if these two is OK.... if these two are OK.
vsureshHe did not like writing ghost stories, and however, he was chasing inspiration for it as he needed to write one.'And however' is not natural English,
vsureshHe did not like writing ghost stories, however,