Both are OK (apart from the minutely picky point that you have a superfluous double space in the second). Some traditional grammars may disapprove of starting a sentence with "and", but in my view there is no problem with this if it's done in a stylistically appropriate way.
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Mr. Tom
Which new cruelty are you going to inflict on me today?
Which new cruelty are you going to subject me to today?