Is this OK: Life is like a box of chocolates and you never know what you’re going to get.
Can you use and here?
balboa1 Is this OK: Life is like a box of chocolates , and you never know what you’re going to get. Can you use and here? Yes.
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balboa1Is this OK: Life is like a box of chocolates, and you never know what you’re going to get.
Can you use and here?
Yes. It doesn't violate any rules of grammar. Several other words can go there as well, for example, 'but' or 'because' or 'however'.
CJ