Always be a highly significant match to the genomes of other mammals?

Should "always be a highly significant match to the genomes of other mammals" be "always be a highly significant match to that of the genomes of other mammals"?.

A gene to match the whole genome does not hold water, after all.

Context:
Another profoundly interesting consequence of the study of multiple genomes has been the ability to do detailed compar- isons of our own DNA sequence with that of other organisms. Using a computer, one can pick a certain stretch of human DNA and assess whether there is a similar sequence in some other species. If one picks the coding region of a human gene (that is, the part that contains the instructions for a protein), and uses that for the search, there will nearly always be a highly significant match to the genomes of other mammals. Many genes will also show discernible but imperfect matches to fish. Some will even find matches to the genomes of simpler organisms such