A major part of their business goes away

Does "A major part of their business goes away" imply that big chunk of their revenues will go away? or that it imply that they as a business will have big losing? This one is confusing...

At 4:02 Well there's an entrenched interest to big companies, laboratory health and quest Diagnostics... 11 billion dollars in revenues they obviously need to stop you or else a major part of their business goes away.