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NL888 Posted 13 years ago
Grammar
A higher rate of cardiovascular events with bardoxolone methyl than with placebo prompted termination of the trial?
Does " A higher rate of cardiovascular events with bardoxolone methyl than with placebo prompted termination of the trial" mean "The use of bardoxolone methyl has a higher rate of cardiovascular events than that of the use of placebo, which led us (the researchers) to finish our trial more quickly"?
Context:
MOre:
http://www.nejm.org/doi/full/10.1056/NEJMoa1306033?query=featured_home
Context:
Conclusions
Among patients with type 2 diabetes mellitus and stage 4 chronic kidney disease, bardoxolone methyl did not reduce the risk of ESRD or death from cardiovascular causes. A higher rate of cardiovascular events with bardoxolone methyl than with placebo prompted termination of the trial. (Funded by Reata Pharmaceuticals; BEACON ClinicalTrials.gov number, NCT01351675.)MOre:
http://www.nejm.org/doi/full/10.1056/NEJMoa1306033?query=featured_home
Top answer
NL888 "The use of bardoxolone methyl has a higher rate of cardiovascular events than that of the use of placebo, which led us (the researchers) to finish our trial more quickly"? No, they stopped the trial because of the danger to the participants.
- NL888 "The use of bardoxolone methyl has a higher rate of cardiovascular events than that of the use of placebo, which led us (the researchers) to finish our trial more quickly"?
- No, they stopped the trial because of the danger to the participants.
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3 Answers
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NL888"The use of bardoxolone methyl has a higher rate of cardiovascular events than that of the use of placebo, which led us (the researchers) to finish our trial more quickly"?No, they stopped the trial because of the danger to the participants.
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NL888which led us (the researchers) to finish our trial more quickly"?Hi, NL.
In my opinion, "finish" is the wrong word. I think "finishing a trial" implies "completion." That is, results were obtained.
I believe the language you quote suggests that the the trial was aborted. That is, it was not completed as planned.
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