Hi, I suggest that it might be helpful if you consider that a comma in writing basically reflects a pause in speaking. If you forget about speaking, the use of commas can often seem like just a whole pile of arbitrary rules. When in doubt about a comma, consider whether or not you would want to pause in speaking.
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Which one of these sentences is correct?
1- My sister, Mary's cat died.
Or 2- My sister's, Mary's cat died.