Hi guys. I am preparing myself for phd applying but Iam not sure about my mottivation letter. could you share your corrections in my sample.
Thanks in advance

I would like to express my interest in the position of -- that I saw advertised on ---
It was while obtaining my B.S. in Microbiology, at the --- University of Iran, which followed by graduate researching in the laboratory where I eventually obtained my M.Sc. in genetics. My dissertation project, completed in 2011, entitled “Association between copy numbers of cytochrome P450 CYP2D and Tamoxifen resistance in patients with breast cancer.” was a quantification of CYP2D6 gene (Tamoxifen metabolizer) as a part of allele variation in the enzyme that has identified to be an important determinant of Tamoxifen’s activity (and toxicity). While the financial and public health impacts of adopting CYP2D6 genotyping in practice could be large, Finally we observed that, CYP2D6 copy number alone, could not guide Tamoxifen treatment and needs evaluation of other parameters such as pharmacogenetic variation in genes that do not predict endoxifen levels (tamoxifen metabolite) but are involved in drug elimination and transport.

As a result of my graduate research work, I served as primary author in the publication. I was also given the opportunity to present my research findings in the form of poster presentations and during invited talks. In addition I also served as a lecturer for undergraduate microbiology and genetic classes at the Shahid Sadoughi University of medical science and Payame Noor University.

My first research experience in personalized medicine of cancer therapy made me to further enhance my research experience repertoire to cancer in an international scientific world. So I moved to Belgium and started new M.Sc at---. with shift from molecular genetics to biomedical science. On my way, I have taken most cancer-related courses and Currently, I am working under supervision of Prof. --, focusing on the role of ATP13A2 (lysosomal transmembrane protein) in cancer cells under homeostatic and stress conditions in cancer cell lines. Understanding these mechanism would make possible the use of more effective treatments, so as to avoid that, in the case of melanoma metastases occur.

During my master life and bachelor degree life due to my internships, laboratory experiences and my research projects, I realized the excitement that I derive from designing experiments and learning something new every day through scientific research. I find it thrilling that the results of each experiment shape my next question and that each day, I know more than the previous one. I am certain that an academic career in science will give me this opportunity and motivation. Since then, I have developed clear goals for my graduate career.

I would like to pursue a Ph.D. degree aiming to learn more about the relationship -- and metabolic diseases or cancer and use these findings in a potential therapeutics in Biomedical Sciences at this university---. At the same time I am sure that the project called ----- link in melanomagenesis and melanoma therapy under the supervision of ---- will help me to get new aspects combining with my master research field and my previous experiences. I am also familiar with --- subject due to some articles and reviews that I have already read. I know that one can acquire new scientific interests during time, but based on my previous experiences, I find targeting and discovery of potential therapeutics very interesting.

I am aware of the dedication and perseverance that is needed to achieve the best results in this field and I believe that my experience will allow me to get it. I think that it is a great opportunity for me to demonstrate my abilities and acquire new skills, so I hope to be selected for this PhD position. I remain at your disposal for any further information, thanking you in advance for your attention.